First American-born Archbishop of New York; first American cardinal. Bishop of Albany (1847-64). Created a cardinal by Blessed Pius IX in 1875. President of St. John's College, now Fordham University, beginning in 1841.
 
SIG - Vintage signature with salutation and title of office on small slip of paper. Accompanied by a circa 1880 steel engraving of Cardinal McCloskey. The pair professionally matted under burgundy leatherette board.